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Delayed development of motor skills (such as sitting and walking), weak muscle tone (hypotonia), and behavioral and emotional difficulties are also possible, but these characteristics vary widely among affected girls and women.Seizures or kidney abnormalities occur in about 10 percent of affected females.

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For example, walking may be delayed and affected girls may exhibit poor coordination and clumsiness.

They also have developmental dyspraxia which affects learning in every domain.

Typically, motor planning skills are deficient, which affects gross and fine motor, speech and language as well as executive function.

Speech and language development is also commonly delayed and may become apparent by approximately one year to 18 months.

Girls with trisomy X have an increased frequency of language-based learning disabilities including reading deficiencies such as dyslexia, reading comprehension deficits and/or reading fluency issues in conjunction with other language-based disabilities.

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